Two-stage continuous biosynthesis of L-lysine.
نویسندگان
چکیده
منابع مشابه
The L box regulon: lysine sensing by leader RNAs of bacterial lysine biosynthesis genes.
Expression of amino acid biosynthesis genes in bacteria is often repressed when abundant supplies of the cognate amino acid are available. Repression of the Bacillus subtilis lysC gene by lysine was previously shown to occur at the level of premature termination of transcription. In this study we show that lysine directly promotes transcription termination during in vitro transcription with B. ...
متن کاملEfficient Production of Enantiopure D-Lysine from L-Lysine by a Two-Enzyme Cascade System
The microbial production of D-lysine has been of great interest as a medicinal raw material. Here, a two-step process for D-lysine production from L-lysine by the successive microbial racemization and asymmetric degradation with lysine racemase and decarboxylase was developed. The whole-cell activities of engineered Escherichia coli expressing racemases from the strains Proteus mirabilis (LYR) ...
متن کامل9 Enzymology of Bacterial Lysine Biosynthesis
Lysine is an essential amino acid in the mammalian diet, but can be synthesised de novo in bacteria, plants and some fungi (Dogovski et al., 2009; Hutton et al., 2007). In bacteria, the lysine biosynthesis pathway, also known as the diaminopimelate (DAP) pathway (Fig. 1), yields the important metabolites meso-2,6-diaminopimelate (meso-DAP) and lysine. Lysine is utilised for protein synthesis in...
متن کاملInhibition of epsilon-poly-L-lysine biosynthesis in Streptomycetaceae bacteria by short-chain polyols.
Antimicrobial epsilon-poly-L-lysine (ePL) is secreted by Streptomycetaceae bacteria, and the mechanism of ePL biosynthesis remains to be elucidated. We previously reported that an unknown ePL derivative accumulates in the culture medium of ePL-producing bacteria when glycerol is added to the culture medium (Nishikawa and Ogawa, Appl. Environ. Microbiol. 68:3575-3581, 2002). In this study, by us...
متن کاملBioefficacy of Lysine from L-lysine Sulfate and L-lysine⋅HCl for 10 to 20 kg Pigs
The objective of this study was to compare the bioefficacy of L-lysine sulfate relative to L-lysine⋅HCl for 10 to 20 kg pigs. Two experiments were conducted to determine the bioefficacy of the two sources of lysine using daily gain, feed conversion, plasma urea nitrogen and nitrogen retention as the response criteria. In experiment 1, 168 crossbred barrows (Landrace×Large White), weaned at 28±3...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kvasny Prumysl
سال: 1982
ISSN: 0023-5830
DOI: 10.18832/kp1982057